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Article

Constitutional epimutation as a mechanism for cancer causality and heritability?

Nature reviews. Cancer - 1 Oct 2015

Hitchins Megan P

Abstract excerpt

Constitutional epimutation, which is an aberration in gene expression due to an altered epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides an alternative mechanism to genetic mutation for cancer predisposition. Observational studies in cancer-affected families have revealed intergenerational inheritance of constitutional epimutation, providing unique insights into the...

Topics

Epigenomics
Genetic Predisposition to Disease
Heredity
Humans
Mutation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26383139
DOI: 10.1038/nrc4001

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