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Article

Epimutations in human disease.

Current topics in microbiology and immunology - 1 Jan 2006

Horsthemke B

Abstract excerpt

Epigenetics is the study of genes during development. Gene expression states are set by transcriptional activators and repressors and locked in by cell-heritable chromatin states. Inappropriate expression or repression of genes can change developmental trajectories and result in disease. Aberrant chromatin states leading to aberrant gene expression patterns (epimutations) have been detected in several...

Topics

DNA Methylation
Epigenesis, Genetic
Genomic Imprinting
Humans
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16909906
DOI: 10.1007/3-540-31181-5_4

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