Article
Epigenetic drivers and genetic passengers on the road to cancer.
Mutation research - 3 Jul 2008
Sawan Carla, Vaissière Thomas, Murr Rabih, Herceg Zdenko
Abstract excerpt
Cancer is traditionally viewed as a primarily genetic disorder, however it is now becoming accepted that cancer is also a consequence of abnormal epigenetic events. Genetic changes and aneuploidy are associated with alterations in DNA sequence, and they are a hallmark of the malignant process. Epigenetic alterations are universally present in human cancer and result in heritable changes in gene expression and...
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