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Article

Impaired survival of regulatory T cells in pulmonary sarcoidosis.

Respiratory research - 16 Sept 2015

Broos Caroline E, van Nimwegen Menno, Kleinjan Alex, ten Berge Bregje, Muskens Femke, in 't Veen Johannes C C M, Annema Jouke T, Lambrecht Bart N, Hoogsteden Henk C, Hendriks Rudi W, Kool Mirjam, van den Blink Bernt

Abstract excerpt

BACKGROUND: Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. Therefore, the aim of this study is to analyze proportions, phenotype, survival, and apoptotic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26376720
DOI: 10.1186/s12931-015-0265-8
PMCID: PMC4574219

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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