Article
Impact of New Genomic Technologies on Understanding Adverse Drug Reactions.
Clinical pharmacokinetics - 1 Apr 2016
Maggo Simran D S, Savage Ruth L, Kennedy Martin A
Abstract excerpt
It is well established that variations in genes can alter the pharmacokinetic and pharmacodynamic profile of a drug and immunological responses to it. Early advances in pharmacogenetics were made with traditional genetic techniques such as functional cloning of genes using knowledge gained from purified proteins, and candidate gene analysis. Over the past decade, techniques for analysing the human genome have...
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