Article
Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence.
Psychiatric genetics - 1 Dec 2015
Ali M Adam, Way Michael J, Marks Michael, Guerrini Irene, Thomson Allan D, Strang John, McQuillin Andrew, Morgan Marsha Y
Abstract excerpt
BACKGROUND: The interpretation of genetic studies on alcohol dependence may be confounded by the co-occurrence of substance dependence, psychiatric disorders and alcohol-related comorbidities, for example, cirrhosis. Significant single-marker and haplotypic associations between polymorphisms in the zinc finger gene, ZNF699, and alcohol dependence were reported in the Irish Affected Sib Pair Study of Alcohol...
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