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Article

Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000

Picarsic Jennifer L, Buryk Melissa A, Ozolek John, Ranganathan Sarangarajan, Monaco Sara E, Simons Jeffrey P, Witchel Selma F, Gurtunca Nursen, Joyce Judith, Zhong Shan, Nikiforova Marina N, Nikiforov Yuri E

Abstract excerpt

The aim of this study was to test the hypothesis that our 60-gene DNA/RNA ThyroSeq v2 next-generation sequence (NGS) assay would identify additional genetic markers, including gene fusions in sporadic pediatric differentiated thyroid carcinomas (DTC) that had no known molecular alterations. Sporadic pediatric DTCs with informative molecular testing (n=18) were studied. We previously tested 15 cases by our...

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Source

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Identifiers

PMID: 26367451
DOI: 10.2350/15-07-1667-OA.1
PMCID: PMC5894824

Genes

BRAF
ETV6
NTRK3
RET
HRAS
KRAS
NRAS
NTRK1
PAX8
TPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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