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Article

The Neuroprotective Role of Insulin Against MPP+‐Induced Parkinson's Disease in Differentiated SH‐SY5Y Cells

14 Sept 2015

Abstract excerpt

Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SN). Retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells (SH-SY5Y+RA) have been broadly utilized in studies of mechanisms of the pathogenesis underlying 1-Methyl-4-phenyl pyridinium (MPP(+))-induced PD...

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PMID: 26364587
DOI: 10.1002/jcb.25376

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