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Article

PD-1 Blockade Can Restore Functions of T-Cells in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma In Vitro.

PloS one - 1 Jan 2015

Quan Lina, Chen Xue, Liu Aichun, Zhang Yan, Guo Xiuchen, Yan Shujie, Liu Yue

Abstract excerpt

Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+DLBCL) is an aggressive malignancy that is largely resistant to current therapeutic regimens, and is an attractive target for immune-based therapies. Anti-programmed death-1 (PD-1) antibodies showed encouraging anti-tumor effects in both preclinical models and advanced solid and hematological malignancies, but its efficacy against EBV+DLBCL is...

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Share to Cell Line, Transformed
Share to Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Immunologic Memory

Share to Lymphocyte Culture Test, Mixed

Share to Lymphoma, Large B-Cell, Diffuse

Share to Programmed Cell Death 1 Receptor

Share to T-Lymphocyte Subsets

Source

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Identifiers

PMID: 26361042
DOI: 10.1371/journal.pone.0136476
PMCID: PMC4567291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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