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Article

CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Vachey Gabriel, Déglon Nicole

Abstract excerpt

This chapter describes the potential use of viral-mediated gene transfer in the central nervous system for genome editing in the context of Huntington's disease. Here, we provide protocols that cover the design of various genome editing strategies, the cloning of CRISPR/Cas9 elements into lentiviral vectors, and the assessment of cleavage efficiency, as well as potential unwanted effects.

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Identifiers

PMID: 29856031
DOI: 10.1007/978-1-4939-7825-0_21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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