Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: Clinical and biologic correlations.

doi:10.1002/gcc.22293

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: Clinical and biologic correlations.

Genes, chromosomes & cancer - 1 Dec 2015

Rigolin Gian Matteo, del Giudice Ilaria, Formigaro Luca, Saccenti Elena, Martinelli Sara, Cavallari Maurizio, Lista Enrico, Tammiso Elisa, Volta Eleonora, Lupini Laura, Bassi Cristian, Bardi Antonella, Sofritti Olga, Daghia Giulia, Cavazzini Francesco, Marinelli Marilisa, Tavolaro Simona, Guarini Anna, Negrini Massimo, Foà Robin, Cuneo Antonio

Abstract excerpt

To clarify whether karyotype aberrations (KA) involving regions not covered by the standard fluorescence in situ hybridization (FISH) panel have independent prognostic relevance, we evaluated KA by conventional cytogenetics in a learning cohort (LC; n = 166) and a validation cohort (VC; n = 250) of untreated chronic lymphocytic leukemia (CLL) patients. In the VC, novel mitogens were used to improve metaphase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytogenetics

Share to Immunoglobulin Heavy Chains

Share to Interleukin-2

Share to Mitogens

Share to Receptor, Notch1

Share to Ribonucleoprotein, U2 Small Nuclear

Share to RNA Splicing Factors

Source

Open in PubMed

Identifiers

PMID: 26355802
DOI: 10.1002/gcc.22293

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: Clinical and biologic correlations.PMID 26355802Read ↗

Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with “normal” FISH: correlations with clinicobiologic parametersSemantic proximity Read ↗

Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlationsSemantic proximity Read ↗

An extensive molecular cytogenetic characterization in high-risk chronic lymphocytic leukemia identifies karyotype aberrations and TP53 disruption as predictors of outcome and chemorefractoriness.Semantic proximity Read ↗

Genetic Abnormalities in Chronic Lymphocytic Leukemia: Where We Are and Where We GoSemantic proximity Read ↗

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impactSemantic proximity Read ↗

In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristicsSemantic proximity Read ↗

Biological significance and prognostic/predictive impact of complex karyotype in chronic lymphocytic leukemiaSemantic proximity Read ↗

Major prognostic value of complex karyotype in addition to TP53 and IGHV mutational status in first-line chronic lymphocytic leukemia.Semantic proximity Read ↗

Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapySemantic proximity Read ↗

The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendationsSemantic proximity Read ↗

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia.Semantic proximity Read ↗

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.