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Antibacterial effect of mesenchymal stem cells against <i>Escherichia coli</i> is mediated by secretion of beta‐ defensin‐ 2 via toll‐ like receptor 4 signalling

9 Sept 2015

Abstract excerpt

Recently, we demonstrated that intratracheal transplantation of human umbilical cord blood- derived mesenchymal stem cells (MSCs) attenuates Escherichia (E) coli- induced acute lung injury primarily by down- modulating inflammation and enhancing bacterial clearance iQn mice. This study was performed to elucidate the mechanism underlying the antibacterial effects of MSCs. The growth of E. coli in vitro was...

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PMID: 26350435
DOI: 10.1111/cmi.12522

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