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Article

PD-L1 gene polymorphism and high level of plasma soluble PD-L1 protein may be associated with non-small cell lung cancer.

The International journal of biological markers - 11 Nov 2015

Cheng Sensen, Zheng Jinsong, Zhu Jingyan, Xie Chao, Zhang Xia, Han Xiao, Song Bao, Ma Yuan, Liu Jie

Abstract excerpt

BACKGROUND: PD-1 and its ligand PD-L1 belong to the co-inhibition molecules, which can downregulate immune responses. The PD-L1 polymorphism and the level of soluble PD-L1 (sPD-L1) were investigated in non-small cell lung cancer (NSCLC). METHODS: A total of 288 NSCLC patients and 300 controls were enrolled. An A/C polymorphism at position 8923 in the PD-L1 gene was genotyped using the polymerase chain...

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Identifiers

PMID: 26349666
DOI: 10.5301/jbm.5000170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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