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Article

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.

Cell reports - 22 Sept 2015

Tsujimura Keita, Irie Koichiro, Nakashima Hideyuki, Egashira Yoshihiro, Fukao Yoichiro, Fujiwara Masayuki, Itoh Masayuki, Uesaka Masahiro, Imamura Takuya, Nakahata Yasukazu, Yamashita Yui, Abe Takaya, Takamori Shigeo, Nakashima Kinichi

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by MECP2 mutations. Although emerging evidence suggests that MeCP2 deficiency is associated with dysregulation of mechanistic target of rapamycin (mTOR), which functions as a hub for various signaling pathways, the mechanism underlying t...

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Source

Identifiers

PMID: 26344767
DOI: 10.1016/j.celrep.2015.08.028

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26344767-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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