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Article

The impact of CYP2C19 polymorphisms on citalopram metabolism in patients with major depressive disorder.

Journal of clinical pharmacy and therapeutics - 1 Dec 2015

Uckun Z, Baskak B, Ozel-Kizil E T, Ozdemir H, Devrimci Ozguven H, Suzen H S

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Genetic variations in drug-metabolizing enzyme genes change drug pharmacokinetics and response. CYP2C19 is a clinically important enzyme that metabolizes citalopram (CIT). The objective of this study was to determine CYP2C19 genetic polymorphisms and to evaluate the impact of these polymorphisms on the metabolism of citalopram in a sample of the Turkish population. We also assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 26343256
DOI: 10.1111/jcpt.12320

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CIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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