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Article

Genetic polymorphisms of cytochrome P450 enzymes influence metabolism of the antidepressant escitalopram and treatment response.

Pharmacogenomics - 1 Apr 2010

Tsai Ming-Hsien, Lin Keh-Ming, Hsiao Mei-Chun, Shen Winston W, Lu Mong-Liang, Tang Hwa-Sheng, Fang Chun-Kai, Wu Chi-Shin, Lu Shao-Chun, Liu Shu Chih, Chen Chun-Yu, Liu Yu-Li

Abstract excerpt

AIMS: The antidepressant escitalopram (S-CIT) is metabolized by the cytochrome-P450 (CYP) enzymes CYP 2D6, 2C19 and 3A4. This study evaluated the impact of CYP2D6, 2C19 and 3A4 genetic polymorphisms on plasma concentrations of S-CIT and patient treatment response. MATERIALS & METHODS: A total of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20350136
DOI: 10.2217/pgs.09.168

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CIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20350136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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