Article
CYP2C19 variation and citalopram response.
Pharmacogenetics and genomics - 1 Jan 2011
Mrazek David A, Biernacka Joanna M, O'Kane Dennis J, Black John L, Cunningham Julie M, Drews Maureen S, Snyder Karen A, Stevens Susanna R, Rush Augustus John, Weinshilboum Richard M
Abstract excerpt
OBJECTIVE: Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas CYP2D6 plays a secondary role. METHODS: The Sequenced Treatment Alternatives to Relieve Depression sample was used...
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