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Article

Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.

Brain, behavior, and immunity - 1 Jan 2016

Carroll Judith E, Cole Steven W, Seeman Teresa E, Breen Elizabeth C, Witarama Tuff, Arevalo Jesusa M G, Ma Jeffrey, Irwin Michael R

Abstract excerpt

Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined. Key cellular events seen with aging, which are thought to contribute to disease, may be particularly sensitive to sleep loss. We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26336034
DOI: 10.1016/j.bbi.2015.08.024
PMCID: PMC4679552

Genes

PSD
NFKB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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