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Article

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.

Molecular neurodegeneration - 3 Sept 2015

Wang Guohao, Yang Huaqiang, Yan Sen, Wang Chuan-En, Liu Xudong, Zhao Bentian, Ouyang Zhen, Yin Peng, Liu Zhaoming, Zhao Yu, Liu Tao, Fan Nana, Guo Lin, Li Shihua, Li Xiao-Jiang, Lai Liangxue

Abstract excerpt

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is a nuclear protein, but it is redistributed in the neuronal cytoplasm in both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Because small transgenic animal models often lack cytoplasmic TDP-43, how the cytoplasmic accumulation of TDP-43 contributes to these diseases remains unclear. The current study is aimed at studying the...

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Identifiers

PMID: 26334913
DOI: 10.1186/s13024-015-0036-5
PMCID: PMC4557629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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