Article
Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.
The heart surgery forum - 30 Aug 2015
Shah Asad A, Gregory Simon G, Krupp Deidre, Feng Sheng, Dorogi Allison, Haynes Carol, Grass Elizabeth, Lin Shu S, Hauser Elizabeth R, Kraus William E, Shah Svati H, Hughes G Chad
Abstract excerpt
BACKGROUND: Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized. We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients. METHODS: Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves....
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