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Article

Genetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.

The Journal of bone and joint surgery. American volume - 2 Sept 2015

Haller Gabe, Alvarado David M, Willing Marcia C, Braverman Alan C, Bridwell Keith H, Kelly Michael, Lenke Lawrence G, Luhmann Scott J, Gurnett Christina A, Dobbs Matthew B

Abstract excerpt

BACKGROUND: Scoliosis is a feature of several genetic disorders that are also associated with aortic aneurysm, including Marfan syndrome, Loeys-Dietz syndrome, and type-IV Ehlers-Danlos syndrome. Life-threatening complications of aortic aneurysm can be decreased through early diagnosis. Genetic screening for mutations in populations at risk, such as patients with adolescent idiopathic scoliosis, may improve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26333736
DOI: 10.2106/JBJS.O.00290
PMCID: PMC4551173

Genes

FBN1
SMAD3
TGFBR1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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