Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis.

doi:10.1002/jor.1100140621

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Article

Genetic analysis of structural elastic fiber and collagen genes in familial adolescent idiopathic scoliosis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 1996

Miller N H, Mims B, Child A, Milewicz D M, Sponseller P, Blanton S H

Abstract excerpt

Adolescent idiopathic scoliosis is a genetic disorder of unknown etiology. Scoliosis is a clinical feature of inherited connective-tissue disorders including Marfan syndrome. Mutations within the gene of FBN1 (fibrillin 15), a component of the extracellular matrix, are now linked to Marfan syndro...

Topics

Adolescent
Collagen
Elastic Tissue
Elastin
Female
Fibronectins
Genes
Genotype
Humans
Lod Score
Male
Pedigree
Scoliosis

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