Article
Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.
Cellular microbiology - 1 Mar 2016
Rijpma Sanna R, van der Velden Maarten, González-Pons Maria, Annoura Takeshi, van Schaijk Ben C L, van Gemert Geert-Jan, van den Heuvel Jeroen J M W, Ramesar Jai, Chevalley-Maurel Severine, Ploemen Ivo H, Khan Shahid M, Franetich Jean-Francois, Mazier Dominique, de Wilt Johannes H W, Serrano Adelfa E, Russel Frans G M, Janse Chris J, Sauerwein Robert W, Koenderink Jan B, Franke-Fayard Blandine M
Abstract excerpt
Multidrug resistance-associated proteins (MRPs) belong to the C-family of ATP-binding cassette (ABC) transport proteins and are known to transport a variety of physiologically important compounds and to be involved in the extrusion of pharmaceuticals. Rodent malaria parasites encode a single ABC transporter subfamily C protein, whereas human parasites encode two: MRP1 and MRP2. Although associated with drug...
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