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Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei

27 Apr 2022

Abstract excerpt

Malaria remains a global health problem causing more than 400,000 deaths annually. Plasmodium parasites, the causative agents of malaria, replicate asexually in red blood cells (RBCs) of their vertebrate host, while a subset differentiates into sexual stages (gametocytes) for mosquito transmission. Parasite replication and gametocyte maturation in the erythropoietic niches of the bone marrow and spleen contribute...

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PMID: 35476438
DOI: 10.1126/sciadv.abm7348

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