Article
Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.
Alcoholism, clinical and experimental research - 1 Oct 2015
Summa Keith C, Jiang Peng, Fitzpatrick Karrie, Voigt Robin M, Bowers Samuel J, Forsyth Christopher B, Vitaterna Martha H, Keshavarzian Ali, Turek Fred W
Abstract excerpt
BACKGROUND: Chronic alcohol exposure exerts numerous adverse effects, although the specific mechanisms underlying these negative effects on different tissues are not completely understood. Alcohol also affects core properties of the circadian clock system, and it has been shown that disruption of circadian rhythms confers vulnerability to alcohol-induced pathology of the gastrointestinal barrier and liver....
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