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Article

TOLLIP, MUC5B, and the Response to N-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine - 15 Dec 2015

Oldham Justin M, Ma Shwu-Fan, Martinez Fernando J, Anstrom Kevin J, Raghu Ganesh, Schwartz David A, Valenzi Eleanor, Witt Leah, Lee Cathryn, Vij Rekha, Huang Yong, Strek Mary E, Noth Imre

Abstract excerpt

RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. The genes TOLLIP and MUC5B play important roles in lung host defense, which is an immune process influenced by oxidative signaling. Whether polymorphisms in TOLLIP and MUC5B modify the effect of immunosuppressive and antioxidant therapy in individuals with IPF is unknown. OBJECTIVES: To determine whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26331942
DOI: 10.1164/rccm.201505-1010OC
PMCID: PMC4731723

Genes

TOLLIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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