Mutations on the α2-Globin Gene That May Trigger α(+)-Thalassemia.

Abstract excerpt

In the present study, a total of 11 individuals with hypochromic microcytic anemia who did not reveal the most common α-thalassemia (α-thal) deletions or mutations, were subjected to more investigations by DNA sequencing of the α-globin genes. Seven novel nondeletional α-thal mutations localized on the α2-globin gene in the heterozygous state were identified. These mutations either corrupted regulatory splice...

Topics

• Adolescent
• Adult
• Alleles
• Child
• Computational Biology
• Erythrocyte Indices
• Exons