Article
Mutations on the α2-Globin Gene That May Trigger α(+)-Thalassemia.
Hemoglobin - 1 Jan 2015
Farashi Samaneh, Vakili Shadi, Garous Negin F, Ashki Mehri, Imanian Hashem, Azarkeivan Azita, Najmabadi Hossein
Abstract excerpt
In the present study, a total of 11 individuals with hypochromic microcytic anemia who did not reveal the most common α-thalassemia (α-thal) deletions or mutations, were subjected to more investigations by DNA sequencing of the α-globin genes. Seven novel nondeletional α-thal mutations localized on the α2-globin gene in the heterozygous state were identified. These mutations either corrupted regulatory splice...
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