Article
The molecular basis of α-thalassemia: a model for understanding human molecular genetics.
Hematology/oncology clinics of North America - 1 Dec 2010
Higgs Douglas R, Gibbons Richard J
Abstract excerpt
Down-regulation of α-globin synthesis causes α-thalassemia with underproduction of fetal (HbF, α(2)γ(2)) and adult (HbA, α(2)β(2)) hemoglobin. This article focuses on the human α-globin cluster, which has been characterized in great depth over the past 30 years. In particular the authors describe how the α genes are normally switched on during erythropoiesis and switched off as hematopoietic stem cells commit to...
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