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Article

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

31 Aug 2015

Abstract excerpt

Mutations in parkin lead to early-onset autosomal recessive Parkinson's disease (PD) and inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the ventral midbrain of mice leads to an age-dependent loss of dopamine neurons that is dependent on the accumulation of parkin interacting substrate (PARIS), zinc finger protein 746 (ZNF746), and its transcriptional repression of...

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PMID: 26324925
DOI: 10.1073/pnas.1500624112

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Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respirationPMID 26324925Read ↗

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Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo.Semantic proximity Read ↗

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Lack of Parkin Anticipates the Phenotype and Affects Mitochondrial Morphology and mtDNA Levels in a Mouse Model of Parkinson's Disease.Semantic proximity Read ↗

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.Semantic proximity Read ↗

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