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Article

Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.

The New England journal of medicine - 1 Oct 2015

Morillo Carlos A, Marin-Neto Jose Antonio, Avezum Alvaro, Sosa-Estani Sergio, Rassi Anis, Rosas Fernando, Villena Erick, Quiroz Roberto, Bonilla Rina, Britto Constança, Guhl Felipe, Velazquez Elsa, Bonilla Laura, Meeks Brandi, Rao-Melacini Purnima, Pogue Janice, Mattos Antonio, Lazdins Janis, Rassi Anis, Connolly Stuart J, Yusuf Salim

Abstract excerpt

BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed for a mean of 5.4 years. The primary outcome in the time-to-event analysis was the first event of any of the...

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Identifiers

PMID: 26323937
DOI: 10.1056/NEJMoa1507574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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