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Inhibitors of UDP-Galactopyranose Mutase Thwart Mycobacterial Growth

1 May 2008

Abstract excerpt

Galactofuranose (Galf) residues are fundamental components of the cell wall of mycobacteria. A key enzyme, UDP-galactopyranose mutase (UGM), that participates in Galf incorporation mediates isomerization of UDP-Galf from UDP-galactopyranose (UDP-Galp). UGM is of special interest as a therapeutic target because the gene encoding it is essential for mycobacterial viability and there is no comparable enzyme in...

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PMID: 18447352
DOI: 10.1021/ja8018687

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