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Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects

22 Aug 2015

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent lung diseases. Cigarette smoking is the main risk factor for COPD. In this parallel-group clinical study we investigated to what extent the transitions in a chronic-exposure-to-disease model are reflected in the proteome and cellular transcriptome of induced sputum samples. We selected 60 age- and gender-matched individuals for each of the...

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PMID: 26306861
DOI: 10.1016/j.jprot.2015.08.009

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