Article
[Identification of a novel aberrant spliceosome of MPL gene (MPLL391-V392ins12)in patients with myeloproliferative neoplasms].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jul 2015
Tian Ruiyuan, Chen Xiuhua, Chang Jianmei, Zhang Na, Tan Yanhong, Xu Zhifang, Ren Fanggang, Zhao Junxia, Pan Jie, Guo Haixiu, Wang Xiaojuan, Wang Hongwei
Abstract excerpt
OBJECTIVE: To identify the MPL L391-V392ins12 spliceosome and analyze its frequencies in patients with myeloproliferative neoplasms (MPN). METHODS: MPL aberrant spliceosome was identified through reverse transcription polymerase chain reaction (RT-PCR)combined with cloning sequencing. The mutation of this spliceosome in 248 MPN patients and 200 normal people was determined by allele-specific polymerase chain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.