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Article

Disomy 21 in spermatozoa and the paternal origin of trisomy 21 Down syndrome

18 Aug 2015

Abstract excerpt

BACKGROUND: Trisomy 21 Down syndrome is the most common genetic cause for congenital malformations and intellectual disability. It is well known that in the outstanding majority of cases the extra chromosome 21 originates from the mother but only in less than 10 % from the father. The mechanism underlying this striking difference in parental origin of Trisomy 21 Down syndrome is still unknown. However, it seems...

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PMID: 26300975
DOI: 10.1186/s13039-015-0155-2

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