Article
The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.
Science signaling - 18 Aug 2015
Ramsdale Rachel, Jorissen Robert N, Li Frederic Z, Al-Obaidi Sheren, Ward Teresa, Sheppard Karen E, Bukczynska Patricia E, Young Richard J, Boyle Samantha E, Shackleton Mark, Bollag Gideon, Long Georgina V, Tulchinsky Eugene, Rizos Helen, Pearson Richard B, McArthur Grant A, Dhillon Amardeep S, Ferrao Petranel T
Abstract excerpt
Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein kinase kinase (MEK), collectively BRAF/MEK inhibitors. We found that inherent resistance to these agents in BRAF(V600)-mutant melanoma cell lines was associated with high abundance of c-JUN and characteristics of a mesenchymal-like...
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