Association analysis identifies new risk loci for congenital heart disease in Chinese populations.

doi:10.1038/ncomms9082

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association analysis identifies new risk loci for congenital heart disease in Chinese populations.

Nature communications - 18 Aug 2015

Lin Yuan, Guo Xuejiang, Zhao Bijun, Liu Juanjuan, Da Min, Wen Yang, Hu Yuanli, Ni Bixian, Zhang Kai, Yang Shiwei, Xu Jing, Dai Juncheng, Wang Xiaowei, Xia Yankai, Ma Hongxia, Jin Guangfu, Yu Shiqiang, Liu Jiayin, Keavney Bernard D, Goodship Judith A, Cordell Heather J, Wang Xinru, Shen Hongbing, Sha Jiahao, Zhou Zuomin, Chen Yijiang, Mo Xuming, Luo Lingfei, Hu Zhibin

Abstract excerpt

Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW significant (P<5.0 × 10(-8)) evidence of 4 additional CHD susceptibility loci at 4q31.22 (rs1400558, upstream of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Heart Defects, Congenital

Share to Polymorphism, Single Nucleotide

Share to Reproducibility of Results

Source

Open in PubMed

Identifiers

PMID: 26283027
DOI: 10.1038/ncomms9082

Genes

EDNRA
PTPRT
SMARCA2
TBX3
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis identifies new risk loci for congenital heart disease in Chinese populations.PMID 26283027Read ↗

A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations.Semantic proximity Read ↗

Genome-wide compound heterozygosity analysis highlighted 4 novel susceptibility loci for congenital heart disease in Chinese population.Semantic proximity Read ↗

Genetic Diagnostic Yield and Novel Causal Genes of Congenital Heart DiseaseSemantic proximity Read ↗

Genetic and Environmental Contributors To Congenital Heart DiseaseSemantic proximity Read ↗

Genetics of Congenital Heart Disease.Semantic proximity Read ↗

Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heartSemantic proximity Read ↗

CHDbase: A Comprehensive Knowledgebase for Congenital Heart Disease-related Genes and Clinical ManifestationsSemantic proximity Read ↗

Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects.Semantic proximity Read ↗

CHDGKB: a knowledgebase for systematic understanding of genetic variations associated with non-syndromic congenital heart disease.Semantic proximity Read ↗

Computational analysis of congenital heart disease associated SNPs: Unveiling their impact on the gene regulatory systemSemantic proximity Read ↗

Complex genetics and the etiology of human congenital heart disease.Semantic proximity Read ↗

Genetics and Genomics of Congenital Heart Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.