[Discovery and clinical application of mutations in the cancer genome].

Abstract excerpt

Cancer genome/epigenome analyses have identified a wide array of somatic mutations that can confer cancer cell characteristics. These genomic/epigenomic alterations can be targeted for cancer treatment, and, indeed, inhibitors against oncogenic protein-tyrosine kinases have been proved clinically effective. Other types of molecularly targeted therapies, such as epigenetic modifiers, are currently under clinical...

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