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Article

Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics

13 Aug 2015

Abstract excerpt

A number of classes of proteins have been engineered for high stability using consensus sequence design methods. Here we describe the engineering of a novel albumin binding domain (ABD) three-helix bundle protein. The resulting engineered ABD molecule, called ABDCon, is expressed at high levels in the soluble fraction of Escherichia coli and is highly stable, with a melting temperature of 81.5°C. ABDCon binds...

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PMID: 26275855
DOI: 10.1093/protein/gzv040

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