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Article

Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis.

Rheumatology (Oxford, England) - 1 Jan 2016

Burmester Gerd R, Durez Patrick, Shestakova Galina, Genovese Mark C, Schulze-Koops Hendrik, Li Yue, Wang Ying A, Lewitzky Steve, Koroleva Irina, Berneis Anni Agarwal, Lee David M, Hueber Wolfgang

Abstract excerpt

OBJECTIVE: To assess whether preliminary findings of associations between the HLA-DRB1*04 and HLA-DRB1* shared epitope (SE) allelic groups and response to the anti-IL-17A mAb secukinumab in RA were reproducible in an independent RA cohort. METHODS: Biologic-naïve subjects (n = 100) with RA by 2010 criteria with tender/swollen joint counts (each ≥6) and high-sensitivity CRP (hsCRP) >10 mg/l were randomized 2:1 to...

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Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Dose-Response Relationship, Drug

Share to Double-Blind Method

Share to HLA-DRB1 Chains

Share to Infusions, Intravenous

Share to Interleukin-17

Source

Identifiers

PMID: 26268815
DOI: 10.1093/rheumatology/kev258

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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