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Article

Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes.

Virology - 1 Nov 2015

Andino Francisco De Jesús, Grayfer Leon, Chen Guangchun, Chinchar V Gregory, Edholm Eva-Stina, Robert Jacques

Abstract excerpt

To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpoles with Δ64R- or Δ52L-FV3 resulted in significantly lower levels of mortality and viral...

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Source

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Identifiers

PMID: 26264970
DOI: 10.1016/j.virol.2015.07.011
PMCID: PMC4619136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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