Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer.

doi:10.1016/j.lungcan.2015.07.008

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Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2015

Giatromanolaki Alexandra, Kalamida Dimitra, Sivridis Efthimios, Karagounis Ilias V, Gatter Kevin C, Harris Adrian L, Koukourakis Michael I

Abstract excerpt

OBJECTIVES: We investigated the role of lysosomal biogenesis and hydrolase activity in the clinical behavior and postoperative outcome of lung cancer. MATERIALS AND METHODS: Using immunohistochemistry we investigated the expression of the transcription factor EB (TFEB) which orchestrates lysosomal biogenesis, the lysosome membrane protein LAMP2a and of the lysosomal hydrolase cathepsin D in a series of 98...

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Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer.

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