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Article

Mechanisms of drug resistance in kinases

16 Jan 2011

Abstract excerpt

INTRODUCTION: because of their important roles in disease and excellent 'druggability', kinases have become the second largest drug target family. The great success of the BCR-ABL inhibitor imatinib in treating chronic myelogenous leukemia illustrates the high potential of kinase inhibitor (KI) therapeutics, but also unveils a major limitation: the development of drug resistance. This is a significant concern as...

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PMID: 21235428
DOI: 10.1517/13543784.2011.546344

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