[Future targeting of the RAS/RAF/MEK/ERK signaling pathway in oncology: the example of melanoma].

Abstract excerpt

The proliferation, survival and mobility of cancer cells are maintained by deregulation of signaling pathways, including RAS/RAF/MEK/ERK/. Constitutive activation of these pathways is a common event in human cancers. It is most often caused by mutations or altered expression of genes encoding key players in this pathway. Knowledge of the mechanisms of intracellular activation of these circuits has led to the...

Topics

• Antineoplastic Agents
• Drug Discovery
• Genes, ras
• Humans
• MAP Kinase Signaling System
• Melanoma
• Molecular Targeted Therapy
• Mutation
• Signal Transduction
• Skin Neoplasms
• raf Kinases