Article
BRAF Gene and Melanoma: Back to the Future.
International journal of molecular sciences - 27 Mar 2021
Ottaviano Margaret, Giunta Emilio Francesco, Tortora Marianna, Curvietto Marcello, Attademo Laura, Bosso Davide, Cardalesi Cinzia, Rosanova Mario, De Placido Pietro, Pietroluongo Erica, Riccio Vittorio, Mucci Brigitta, Parola Sara, Vitale Maria Grazia, Palmieri Giovannella, Daniele Bruno, Simeone Ester, On Behalf Of Scito Youth
Abstract excerpt
As widely acknowledged, 40-50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS-RAF-MEK-ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment,...
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