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Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status.

Inflammatory bowel diseases - 1 Oct 2015

Stallhofer Johannes, Friedrich Matthias, Konrad-Zerna Astrid, Wetzke Martin, Lohse Peter, Glas Jürgen, Tillack-Schreiber Cornelia, Schnitzler Fabian, Beigel Florian, Brand Stephan

Abstract excerpt

BACKGROUND: Lipocalin-2 (LCN2) is a potent bacteriostatic protein. We aimed to investigate its role as a disease activity marker in patients with inflammatory bowel disease (IBD) and its induction by the Th17 cytokines IL-17A, IL-22, and TNF-α in colonic epithelial cells. Moreover, we analyzed the influence of IBD-associated IL23R alleles on LCN2 serum levels in IBD patients. METHODS: LCN2 serum levels were...

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Identifiers

PMID: 26263469
DOI: 10.1097/MIB.0000000000000515

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LCN2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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