Article
Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy.
The Journal of allergy and clinical immunology - 1 Feb 2016
Koplin Jennifer J, Suaini Noor H A, Vuillermin Peter, Ellis Justine A, Panjari Mary, Ponsonby Anne-Louise, Peters Rachel L, Matheson Melanie C, Martino David, Dang Thanh, Osborne Nicholas J, Martin Pamela, Lowe Adrian, Gurrin Lyle C, Tang Mimi L K, Wake Melissa, Dwyer Terry, Hopper John, Dharmage Shyamali C, Allen Katrina J
Abstract excerpt
BACKGROUND: There is evolving evidence that vitamin D insufficiency may contribute to food allergy, but findings vary between populations. Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels. OBJECTIVE: We sought to investigate whether polymorphisms that lower the DBP could...
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