Article
Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2017
Ashley S E, Tan H-T T, Peters R, Allen K J, Vuillermin P, Dharmage S C, Tang M L K, Koplin J, Lowe A, Ponsonby A-L, Molloy J, Matheson M C, Saffery R, Ellis J A, Martino D
Abstract excerpt
BACKGROUND: Food allergies pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-old infants. Few food allergy genetic risk variants have yet been identified. The Th2 immune gene IL13 is a highly plausible genetic candidate as it is central to the initiation of IgE class switching in B cells. OBJECTIVE: Here, we sought to investigate whether genetic polymorphisms at...
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