Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular screening of the LPCAT1 gene in patients with retinitis pigmentosa without defined mutations in known retinitis pigmentosa genes.

Molecular medicine reports - 1 Oct 2015

Wu Juan, Wang Hong-Ting, Huang Xiu-Feng, Lei Xin-Lan, Lu Qin-Kang, Jin Zi-Bing

Abstract excerpt

Retinitis pigmentosa (RP) is an inherited retinopathy, which affects the photoreceptors in the retina. Lysophosphatidylcholine acyltransferase (LPCAT) is a critical phospholipid biosynthesis enzyme, which promotes the conversion of lysophosphatidylcholine into phosphatidylcholine in the remodeling pathway of PC biosynthesis. A previous study reported a homozygous insertion in the LPCAT1 gene in mice exhibiting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Heterozygote

Share to Mice, Inbred C57BL

Share to Retina

Share to Retinitis Pigmentosa

Source

Identifiers

PMID: 26260533
DOI: 10.3892/mmr.2015.4204

Genes

LPCAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular screening of the LPCAT1 gene in patients with retinitis pigmentosa without defined mutations in known retinitis pigmentosa genes.PMID 26260533Read ↗

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 miceSemantic proximity Read ↗

Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cellsSemantic proximity Read ↗

Targeted next generation sequencing identified novel mutations in RPGRIP1 associated with both retinitis pigmentosa and Leber's congenital amaurosis in unrelated Chinese patients.Semantic proximity Read ↗

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.Semantic proximity Read ↗

Identification and characterisation of the retinitis pigmentosa 1-like1 gene (RP1L1): a novel candidate for retinal degenerationsSemantic proximity Read ↗

PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in mice retinaSemantic proximity Read ↗

Novel Heterozygous Variant in RP1L1 Gene With Retinitis Pigmentosa Phenotype: A Case Report.Semantic proximity Read ↗

Characterization of RP1L1, a highly polymorphic paralog of the retinitis pigmentosa 1 (RP1) gene.Semantic proximity Read ↗

Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.Semantic proximity Read ↗

Gene variants of the phosphatidylcholine synthesis pathway do not contribute to RDS in the Chinese population.Semantic proximity Read ↗

Retinal degeneration caused by mutations in TULP1.Semantic proximity Read ↗

Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.