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Article

Ploidy manipulation and induction of alternate cleavage patterns through inhibition of centrosome duplication in the early zebrafish embryo.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2015

Heier Jonathon, Takle Kendra A, Hasley Andrew O, Pelegri Francisco

Abstract excerpt

BACKGROUND: Whole genome duplication is a useful genetic tool because it allows immediate and complete genetic homozygosity in gynogenetic offspring. A whole genome duplication method in zebrafish, Heat Shock, involves a heat pulse in the period 13-15 min postfertilization (mpf) to inhibit cytokinesis of the first mitotic cycle. However, Heat Shock produces a relatively low yield of gynogenotes. RESULTS: A heat...

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Identifiers

PMID: 26249657
DOI: 10.1002/dvdy.24315
PMCID: PMC4587285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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