Article
Emergence and Selection of a Highly Pathogenic Avian Influenza H7N3 Virus.
Journal of virology - 31 Mar 2020
Beerens Nancy, Heutink Rene, Harders Frank, Bossers Alex, Koch Guus, Peeters Ben
Abstract excerpt
Low-pathogenicity avian influenza (LPAI) viruses of subtypes H5 and H7 have the ability to spontaneously mutate to highly pathogenic (HPAI) virus variants, causing high mortality in poultry. The highly pathogenic phenotype is caused by mutation of the hemagglutinin (HA) cleavage site, but additional mutations may play a role. Evidence from the field for the switch to high pathogenicity remains scarce. This study...
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